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Stefano Tiziani, PhD



Laurea in Chemistry: “Dottore in chimica”; University of Trieste, Trieste, Italy (July 2001)
Ph.D. in Food Science and Nutrition; The Ohio State University, Columbus, Ohio (January 2006)

Research Experience

Sanford-Burnham Medical Research Institute, la Jolla, California
NSF Fellow (16th January 2009– 27th July 2012)
Project: “The control landscape of selective cell death”, coordinated by Dr. Giovanni Paternostro

Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), School of Cancer Sciences, University of Birmingham, Birmingham, UK
Marie Curie Postdoctoral Research Fellow (1st February 2006 – January 2008)
EU Research Fellow (February 2008 – 15th January 2009)
Project: “Metabolomics and Oncology, Transfer of European Technology (MOTET)”, coordinated by Dr. Ulrich L. Günther (School of Cancer Sciences, University of Birmingham) and Drs. Mark R. Viant and Christopher M. Bunce (School of Biosciences, University of Birmingham).

Publications (Peer-Reviewed Journals)

  • Tiziani S, Kang Y, Choi JS, Roberts W, Paternostro G, "Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library" Nature Communications, doi:10.1038/ncomms1562 (2011)
  • Ludwig C, Easton JM, Lodi A, Tiziani S, Manzoor S, Southam AD, Byrne J, Bishop L, He S, Arvanitis TN, Günther UL, Viant MR "Birmingham, Metabolite Library: A publicly accessible database of 1-D and 2-D 1H J-resolved NMR spectra of authentic metabolite standards (BML-NMR)" Metabolomics, pp. 1-11. doi:10.1007/s11306-011-0347-7(2011)
  • Lodi A*, Tiziani S*, Khanim FL, Drayson MT, Günther UL, Bunce CM, Viant MR,"Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation" (*first two authors equal contribution) ACS Chem Biol, 6(2), 169–175(2011)
  • Khanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, Davies NJ, Ride JP, Viant MR, Günther UL, Mountford JC, Schrewe H, Green RM, Murray JA, Drayson MT, and Bunce CM, "Combined bezafibrate and medroxyprogesterone acetate: Potential novel therapy for acute myeloid leukaemia" PLoS ONE 4(12), e8147 (2009)
  • Romanska HM*, Tiziani S*, Howe R, Günther UL, Gulzar Z, Lalani E-N, "NMR detects PI3k/Akt independent Traits Common to Pluripotent Murine Embryonic Stem Cells and their Malignant Counterparts" (*first two authors equal contribution) Neoplasia, 11(12), 1301-1308 (2009)
  • Tiziani S, Lodi A, Khanim FL, Viant MR, Bunce CM, Günther UL, “Metabolomic Profiling of Drug Response in Acute Myeloid Leukaemia Cell Lines” PLoS ONE 4(1), e4251 (2009)
  • Tiziani S, Lopes V, Günther UL, “Early Stage Diagnosis of Oral Cancer Using 1H NMR-based Metabolomics” Neoplasia, 11(3), 269-276 (2009)
  • Tiziani S, Emwas A-H, Lodi A, Ludwig C, Bunce CM, Viant MR, Günther UL, “Optimised Metabolite Extraction from Blood Serum for 1H Nuclear Magnetic Resonance Spectroscopy“ Anal Biochem, 377(1), 16-23 (2008)
  • Tiziani S, Lodi A, Ludwig C, Parsons HM, Viant MR “Effects of the application of different window functions and projection methods on processing of 1H J-resolved nuclear magnetic resonance spectra for metabolomics” Anal Chim Acta, 610( 1) 80-88 (2008)
  • Tiziani S, Schwartz SJ, Vodovotz Y, “Intermolecular interactions in phytochemical model systems studied by NMR diffusion measurements” Food Chem, 107, 962-969 (2008)
  • Lodi A, Tiziani S, Vodovotz Y, “Molecular changes in soy and wheat breads during storage as probed by NMR” J Agric Food Chem, 55, 5850-5857 (2007)
  • Tiziani S, Schwartz SJ, Vodovotz Y, “Profiling of carotenoids in typical red tomato juice by one and two dimensional NMR” J Agric Food Chem, 54, 6094-6100 (2006)
  • Tiziani S, Vodovotz Y, “Rheological studies of a novel functional food: tomato juice with soy germ” J Agric Food Chem, 53, 7267-7273 (2005)
  • Tiziani S, Vodovotz Y, “Rheological effects of soy protein addition to tomato juice” Food Hydrocolloids, 19(1), 45-52 (2005)
  • Bonutti C, Sussich F, Tiziani S, Cesàro A, “Calorimetric study of the early stage of hyaluronan oxidation”. Chapter in Edited Book: Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Chapter 1: Structure of Hyaluronan and its Properties in Solution. Editors: E.A. Balazs and V.C. Hascall (2003)
  • Tiziani S, Sussich F, Cesàro A, “The kinetic of periodate oxidation of carbohydrates 2. Polymeric substrates” Carbohydr Res, 338, 1083-1095 (2003)


  • Giovanni Paternostro, Stefano Tiziani, and William Roberts, "METABOLICALLY CORRECT MEDIA FOR CELL CULTURE". Application no.61/642,897 (2012)

Recent presentations

  • Tiziani S, Kang Y, Feala J, Harjanto R, Roberts W,Paternostro G, "Metabolite profiling of bone marrow and peripheral biofluids from acute lymphoblastic leukemia patients before and after induction therapy", LIPID MAPS Annual Meeting, May 7-8, 2012, La Jolla, CA
  • Tiziani S, Kang Y, Choi JS, Roberts W, Paternostro G, "Metabolic Drug Screening in Leukemia: Moving toward Personalized Medicine", ISSNAF Annual Event, September 17, 2011, Los Angeles, CA
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